Splice Factor SF3B: Potential Drug Target for Various Diseases

Target Name: Splicing factor 3B protein complex

NCBI ID: P5700

Splicing factor 3B protein complex

Other Name(s): SF3B | SF3b | Splicing factor 3b protein

Splice Factor SF3B: Potential Drug Target for Various Diseases

Splicing factor 3B protein complex (SF3B) is a protein that plays a critical role in the process of gene expression and RNA splicing. It is a protein that is expressed in almost all human tissues and is involved in the regulation of splicing efficiency. splice factors are a family of proteins that are highly conserved across different species, and SF3B is one of the best-studied splice factors.

SF3B is a protein that contains 112 amino acid residues and has a molecular weight of 13.9 kDa. It has a characteristic alpha-helices structure and a distinct N-terminal and C-terminal region. The N-terminal region has a putative nucleotide-binding domain and is involved in the interaction with other proteins. The C-terminal region has a conserved acidic and basic region that is involved in the formation of a hydrogen-bonded complex with other proteins.

SF3B is involved in the regulation of splicing efficiency by affecting the activity of splicing factors. It has been shown to interact with several splicing factors, including SF2, SF4, and SF5. SF3B has been shown to play a role in the regulation of splicing efficiency by affecting the binding of splicing factors to the alpha-2 satellite RNA.

SF3B has also been shown to be involved in the regulation of gene expression by affecting the translation of RNA. It has also been shown to interact with the protein translation factor eIF4F and to play a role in the regulation of eIF4F activity. to be involved in the regulation of DNA replication by affecting the activity of the DNA replication factor DFN1.

SF3B is a protein that has been studied extensively in the context of human diseases. It has been shown to be involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, studies have shown that SF3B is involved in the regulation of the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its involvement in the regulation of splicing efficiency and gene expression, SF3B is also a potential drug target. Studies have shown that SF3B is highly interacted with several protein partners, including the transcription factor ASXL1. This suggests that SF3B may be a useful target for small molecule inhibitors of ASXL1, which could be used to treat various diseases.

In conclusion, SF3B is a splice factor that is involved in the regulation of splicing efficiency and gene expression. It has been shown to play a critical role in the regulation of splicing efficiency and has been shown to be involved in the development and progression of various diseases. As a result, SF3B is a potential drug target for small molecule inhibitors of ASXL1, which could be used to treat various diseases. Further research is needed to fully understand the role of SF3B in disease and to develop effective treatments.

Protein Name: Splicing Factor 3B Protein Complex

The "Splicing factor 3B protein complex Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Splicing factor 3B protein complex comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets